Istradefylline forty mg/day increased peak ranges and AUC of CYP3A4 substrates in scientific trials. This effect was not noticed with istradefylline twenty mg/working day. Consider dose reduction of delicate CYP3A4 substrates.
Contraindicated (one)nirmatrelvir will increase the degree or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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Check Closely (one)nebivolol will increase effects of sildenafil by additive vasodilation. Use Warning/Observe. Sildenafil has systemic vasodilatory Qualities and could even further lower blood pressure in individuals taking antihypertensive medications.
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zafirlukast will boost the amount or effect of sildenafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Monitor Closely (1)sotalol improves effects of sildenafil by additive vasodilation. Use Warning/Keep track of. Sildenafil has systemic vasodilatory Homes and should even more lower blood pressure in people taking antihypertensive medications.
Keep track of blood pressure response to sildenafil in patients acquiring concurrent blood pressure lowering therapy.
diltiazem will boost the stage or effect of sildenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
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pindolol increases effects of sildenafil by additive vasodilation. Use Warning/Keep an eye on. Sildenafil has systemic vasodilatory Attributes and may further lower blood pressure in clients taking antihypertensive medications.
carvedilol improves effects of sildenafil by additive vasodilation. Use Warning/Watch. Sildenafil has systemic vasodilatory properties and should further more lower blood pressure in individuals taking antihypertensive medications.
Inform your doctor or pharmacist if the advice regarding how to cope does not support or maybe the side effects worsen.